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  • دکتری (1378)

    فیزیولوژی

    دانشگاه تربیت مدرس،

  • کارشناسی‌ارشد (1373)

    فیزیولوژی

    دانشگاه تربیت مدرس،

  • کارشناسی (1369)

    زیست شناسی

    ،

  • الکتروفیزیولوژی اختلالات صرعی
  • بررسی جریان های سیناپسی

    زمینه تحقیقاتی اصلی بنده بررسی تغییرات ناشی از افزایش تحریک پذیری، به ویژه در بیماری صرع، بر شکل پذیری و انتقالات سیناپسی است. در این زمینه یکی از عوامل بسیار مهمی که می تواند بر سطح تحریک پذیری و متعاقب آن بر تغییرات سیناپسی تأثیر داشته باشد. تحریکات عمقی مغز می باشند. بر این اساس تحقیقاتی با تمرکز بر نقش تحریکات عمقی مغز بر شکل پذیری سیناپسی و انتقالات سیناپسی در مدل های آزمایشگاهی صرع و تشنج در حال انجام است.

    Allergic rhinitis impairs working memory in association with drop of hippocampal–prefrontal coupling

    Morteza Salimi, Sepideh Ghazvineh, Milad Nazari, Kolsoum Dehdar, Mani Garousi, Meysam Zare, Farhad Tabasi, Hamidreza Jamaati, Alireza Salimi, Victoria Barkley, Javad Mirnajafi-Zadeh, Mohammad Reza Raoufy
    Journal PapersBrain Research , 2021 February 11, {Pages 147368 }

    Abstract

    Allergic rhinitis (AR) is a chronic inflammatory disease frequently associated with a deficit in learning and memory. Working memory is an important system for decision making and guidance, which depends on interactions between the ventral hippocampus (vHipp) and the prelimbic prefrontal cortex (plPFC). It is still unclear whether AR influences the activity and coupling of these brain areas, which consequently may impair working memory. The current study aimed to examine alterations of the vHipp-plPFC circuit in a rat model of AR. Our results show decreased working memory performance in AR animals, accompanied by a reduction of theta and gamma oscillations in plPFC. Also, AR reduces coherence between vHipp and plPFC in both theta and gamma

    Rhythmic air-puff into nasal cavity modulates activity across multiple brain areas: A non-invasive brain stimulation method to reduce ventilator-induced memory impairment

    Sepideh Ghazvineh, Morteza Salimi, Milad Nazari, Mani Garousi, Farhad Tabasi, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Javad Mirnajafi-Zadeh, Ehsan Arabzadeh, Mohammad Reza Raoufy
    Journal PapersRespiratory Physiology & Neurobiology , Volume 287 , 2021 May 1, {Pages 103627 }

    Abstract

    Mechanical ventilation (MV) can result in long-term brain impairments that are resistant to treatment. The mechanisms underlying MV-induced brain function impairment remain unclear. Since nasal airflow modulates brain activity, here we evaluated whether reinstating airflow during MV could influence the memory performance of rats after recovery. Rats were allocated into two study groups: one group received rhythmic air-puff into the nasal cavity during MV and a control group that underwent ventilation without air-puff. During MV, air-puffs induced time-locked event potentials in OB, mPFC and vHPC and significantly increased the oscillatory activity at the air-puff frequency. Furthermore, in mPFC and vHPC, (but not in OB), delta and theta osc

    Electromagnetic field protects against cognitive and synaptic plasticity impairment induced by electrical kindling in rats

    Sina Khajei, Javad Mirnajafi-Zadeh, Vahid Sheibani, Meysam Ahmadi-Zeidabadi, Yaser Masoumi-Ardakani, Mohammad Amin Rajizadeh, Khadijeh Esmaeilpour
    Journal PapersBrain Research Bulletin , 2021 March 19, {Pages }

    Abstract

    Kindling results in abnormal synaptic potentiation and significant impairment in learning and memory. Electromagnetic field (EMF) effects on learning and memory in kindled animals and its effects on hippocampal neural activity are largely unknown. In the current study, the effects of EMF on learning and memory, as well as hippocampal synaptic plasticity, in kindled rats were investigated. EMF (10 m T; 100 Hz) was applied to fully kindled animals one hour/day for a period of one week. The behavioral and electrophysiological studies were performed 24 hours following the EMF application. The kindled rats showed spatial learning deficits during the training phase of the Morris water maze (MWM) test. Moreover, there were increments in es

    CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: a potential role for NAD+ homeostasis

    Shima Khodaverdian, Elahe Dashtban-Moghadam, Bahareh Dabirmanesh, Javad Mirnajafi-Zadeh, Mohammad Taleb, Khosro Khajeh, Yaghoub Fathollahi
    Journal PapersBrain Research , 2021 April 28, {Pages 147509 }

    Abstract

    In spite of long-term intensive scientific research efforts, there are still many issues concerning the mechanisms of epileptogenesis and epilepsy to be resolved. Temporal lobe, in particular hippocampus, is vulnerable to epileptogenic process. Herein, electrical kindling model of temporal lobe were analyzed using proteomic approach. A dramatic decrease in nicotinamide adenine dinucleotide (NAD+) level was exhibited during the kindling procedure in hippocampus. After stage 3, high CD38 expression was detected by qPCR, nano-liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS) and western blot analysis. An increase in expression of CD38/NADase activity was observed during the kindling procedure in hippocampus that represent it as on

    The role of α adrenergic receptors in mediating the inhibitory effect of electrical brain stimulation on epileptiform activity in rat hippocampal slices

    Nooshin Ahmadirad, Yaghoub Fathollahi, Mahyar Janahmadi, Zahra Ghasemi, Amir Shojaei, Mahmoud Rezaei, Victoria Barkley, Javad Mirnajafi-Zadeh
    Journal PapersBrain Research , 2021 April 19, {Pages 147492 }

    Abstract

    The Inhibitory effect of electrical low-frequency stimulation (LFS) on neuronal excitability and seizure occurrence has been indicated in experimental models, but the precise mechanism has not established. This investigation was intended to figure out the role of α1 and α2 adrenergic receptors in LFS' inhibitory effect on neuronal excitability. Epileptiform activity induced in an in vitro rat hippocampal slice preparation by high K+ ACSF and LFS (900 square wave pulses at 1 Hz,) was administered at the beginning of epileptiform activity to the Schaffer collaterals. In CA1 pyramidal neurons, the electrophysiological properties were measured at the baseline, before high K+ ACSF washout, and at 15 min after high K+ ACSF washout using whole-c

    Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

    Mona Faraz, Nastaran Kosarmadar, Mahmoud Rezaei, Meysam Zare, Mohammad Javan, Victoria Barkley, Amir Shojaei, Javad Mirnajafi‑Zadeh
    Journal PapersActa Neurobiol Exp , Volume 81 , 2021 January 1, {Pages 43-57 }

    Abstract

    Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. TLE is characterized by recur‑rent, spontaneous seizures that originate from the temporal lobe (Falconer et al., 1964). The main thera‑peutic intervention for epileptic patients is antiepilep‑tic drugs, but 20–30% of epileptic patients are drug re‑sistant (Schmidt and Schachter, 2014). Therefore, more research has been dedicated to finding new therapies for epilepsy.Over the last decade, deep brain stimulation has been suggested as a treatment for patients with drug‑resistant epilepsy and patients who are not sur‑gical resection candidates (Jobst et al., 2010). Low fre‑quency stimulation (LFS), in the range of 0.5 to 5 Hz, has been shown to suppress seiz

    Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network

    Leila Sadeghi, Albert Anatolyevich Rizvanov, Bahareh Dabirmanesh, Ilnur Ildusovich Salafutdinov, Mohammad Sayyah, Amir Shojaei, Javad Zahiri, Javad Mirnajafi-Zadeh, Babak Khorsand, Khosro Khajeh, Yaghoub Fathollahi
    Journal PapersScientific reports , Volume 11 , Issue 1, 2021 April 15, {Pages 12-Jan }

    Abstract

    Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures. A total of 144 differently expressed proteins in both left and right hippocampi by two-dimensional electrophoresis coupled to matrix-assisted laser desorption-mass spectrometry were identified across the rat models of epilepsy. Based on network analysis, the majority of differentially expressed proteins were associated with Ca 2+ homeostasis. Changes in ADP-ribosyl cyclase (ADPRC), lysophosphatidic acid receptor 3 (LPAR3), calreticulin, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), synaptosomal nerve-associated protein 25 (SNAP 25) and transgelin 3 protein

    Group I metabotropic glutamate receptors contribute to the antiepileptic effect of electrical stimulation in hippocampal CA1 pyramidal neurons

    Z Ghasemi, N Naderi, A Shojaei, MR Raoufy, N Ahmadirad, V Barkley, ...
    Journal Papers , , {Pages }

    Abstract

    Modeling plasticity during epileptogenesis by long short term memory neural networks

    M Shahpari, M Hajji, J Mirnajafi-Zadeh, P Setoodeh
    Journal Papers , , {Pages }

    Abstract

    Corrigendum to" Enhanced Remyelination Following Lysolecithin-induced Demyelination in Mice Under Treatment with Fingolimod (FTY720)"[Neuroscience 311 (2015) 34-44]

    A Yazdi, H Baharvand, M Javan
    Journal Papers , , {Pages }

    Abstract

    Low-Frequency Stimulation Prevents Kindling-Induced Impairment through the Activation of the Endocannabinoid System

    S Khajei, K Esmaeilpour, J Mirnajafi-Zadeh, V Sheibani, S Rezakhani, ...
    Journal Papers , , {Pages }

    Abstract

    Pulsed high magnetic field-induced reversible blood-brain barrier permeability to enhance brain-targeted drug delivery

    S Heydarheydari, SM Firoozabadi, J Mirnajafi-Zadeh, Z Shankayi
    Journal Papers , , {Pages }

    Abstract

    Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats

    M Rezaei, N Ahmadirad, Z Ghasemi, A Shojaei, MR Raoufy, V Barkley, ...
    Journal Papers , , {Pages }

    Abstract

    Online analysis of local field potentials for seizure detection in freely moving rats

    Meysam Zare, Milad Nazari, Amir Shojaei, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh
    Journal PapersIranian Journal of Basic Medical Sciences , Volume 23 , Issue 2, 2020 February 1, {Pages 173-177 }

    Abstract

    Objective (s): Seizure detection during online recording of electrophysiological parameters is very important in epileptic patients. In the present study, online analysis of field potential recordings was used for detecting spontaneous seizures in epileptic animals.Materials and Methods: Epilepsy was induced in rats by pilocarpine injection. During the chronic period of the pilocarpine model, local field potential (LFP) recording was run for at least 24 hr. At the same time, video monitoring of the animals was done to determine the real time of seizure occurrence. Both power and sample entropy of LFP were used for online analysis.Results: Obtained results showed that changes in LFP power are a better index for seizure detection. In addition

    Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation

    Masoumeh Gholami, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Mohamad Javan, Saeed Semnanian, Nasser Naghdi, Yaghoub Fathollahi
    Journal PapersExperimental Brain Research , 2020 March 12, {Pages 07-Jan }

    Abstract

    Herein field recordings were utilized to test the effects of a transient period of pentylenetetrazol (PTZ) treatment on theta-burst long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses as well as RT-PCR was used to investigate the effects of the combination of the pharmacological treatment and the theta-burst LTP induction on the expression of NMDA subunit mRNA in hippocampal slices. The slope of field excitatory postsynaptic potential (fEPSP) was unaffected while the population spike amplitude and area were increased by a transient period of PTZ treatment (3?mM, 10?min). After a theta burst, a brief PTZ exposure can lead to an enhancement of LTP as documented by fEPSP recording. The effect can be blocked by a s

    Evaluation of changes expression of D1, mGluR1 and CD38 genes after electrical kindling and treatment with low-frequency stimulation in rat

    Khosro Khajeh, Javad Mirnajafi-Zadeh, Bahareh Dabirmanesh, Shima Khodaverdian
    Journal PapersModares Journal of Biotechnology , Volume 11 , Issue 1, 2020 March 10, {Pages 0-0 }

    Abstract

    Evaluation of changes expression of D1 mGluR1 and CD38 genes after electrical kindling and treatment with low-frequency stimulation in rat-Tarbiat Modares University Journals System-Modares Journal of Biotechnology

    PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells

    Marzieh Darvishi, Hatef Ghasemi Hamidabadi, Sajad Sahab Negah, Ardeshir Moayeri, Taki Tiraihi, Javad Mirnajafi-Zadeh, Ali Jahanbazi Jahan-Abad, Amir Shojaei
    Journal PapersIranian Journal of Basic Medical Sciences , Volume 23 , Issue 4, 2020 April 1, {Pages 431-438 }

    Abstract

    Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim of this study was to compare the efficiency of two-dimensional with a three-dimensional culture system in their ability to generate functional motor neuron-like cells from adipose-derived stem cells. Materials and Methods: We compared motor neuron-like cells derived from rat adipose tissue in differentiation, adhesion, proliferation, and functional properties on two-dimension

    Therapeutic effects of transplanted exosomes containing miR-29b to a rat model of Alzheimer’s disease

    Yavar Jahangard, Hamideh Monfared, Arman Moradi, Meysam Zare, Javad Mirnajafi-Zadeh, Seyd Javad Mowla
    Journal PapersFrontiers in Neuroscience , Volume 14 , 2020 January , {Pages 564 }

    Abstract

    Alzheimer's disease (AD) is a complex neurodegenerative disorder with no definite treatment. The expression of miR-29 family is significantly reduced in AD, suggesting a part for the family members in pathogenesis of the disease. The recent emergence of microRNA (miRNA)-based therapeutic approaches is emphasized on the efficiency of miRNA transfer to target cells. The endogenously-made secretory vesicles could provide a biological vehicle for drug delivery. Characteristics such as small sizes, the ability to cross the blood-brain barrier, the specificity in binding to the right target cells, and most importantly the capacity to be engineered as drug carriers have made exosomes desirable vehicles to deliver genetic materials to the central n

    The role of dopamine D2-like receptors in a “depotentiation-like effect” of deep brain stimulation in kindled rats

    Azam Sadeghian, Zahra Salari, Hossein Azizi, Mohammad Reza Raoufy, Amir Shojaei, Nastaran Kosarmadar, Meysam Zare, Mahmoud Rezaei, Victoria Barkley, Mohammad Javad, Yaghoub Fathollahi, Javad Mirnajafi-Zadeh
    Journal PapersBrain Research , 2020 April 3, {Pages 146820 }

    Abstract

    The mechanisms involved in the anti-seizure effects of low-frequency stimulation (LFS) have not been completely determined. However, Gi-protein-coupled receptors, including D2-like receptors, may have a role in mediating these effects. In the present study, the role of D2-like receptors in LFS’ anti-seizure action was investigated. Rats were kindled with semi-rapid (6 stimulations per day), electrical stimulation of the hippocampal CA1 area. In LFS-treated groups, subjects received four trials of LFS at 5 min, 6 h, 24 h, and 30 h following the last kindling stimulation. Each LFS set occurred at 5 minute intervals, and consisted of 4 trains. Each train contained 200, 0/1 ms long, monophasic square wave pulses at 1 Hz. Haloperidol (D2-like

    The locus coeruleus noradrenergic system gates deficits in visual attention induced by chronic pain

    Parisa Moazen, Mona Torabi, Hossein Azizi, Yaghoub Fathollahi, Javad Mirnajafi-Zadeh, Saeed Semnanian
    Journal PapersBehavioural Brain Research , 2020 March 18, {Pages 112600 }

    Abstract

    Despite years of research on pain comorbidity with affective disorders and cognitive deficits, it is still unclear how deficit in attention co-occurs with chronic pain. It is likely that altered neuroplasticity and or dysregulated neurotransmitters induced by chronic pain, at which pain and cognitive processing systems overlap, may have a negative effect on cognitive processing such as attention. One of the main common networks involved in attentional and pain processing is the noradrenergic system originating from the locus coeruleus (LC). We hypothesized that heightened noradrenaline release from LC induced by chronic pain could cause a deficit in visual attention. For this purpose, performance on the 5-choice serial reaction time test (5

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    دروس نیمسال جاری

    • دكتري
      مباحث جديد و پيشرفته در فيزيولوژي سلول ( واحد)
      دانشکده علوم پزشکی، گروه فيزيولوژي
    • دكتري
      مباحث جديد و پيشرفته در اعصاب و حواس ويژه ( واحد)
    • دكتري
      مباحث ويژه در مغز و شناخت 2 ( واحد)
    • كارشناسي ارشد
      بيوفيزيك ( واحد)

    دروس نیمسال قبل

    • دكتري
      علوم اعصاب شناختي زبان ( واحد)
      دانشکده علوم پزشکی، گروه زبان شناسي
    • كارشناسي ارشد
      فيزيولوژي غدد درون ريز ( واحد)
    • دكتري
      كارورزي باليني اعصاب ( واحد)
    • دكتري
      نوروبيولو ژي سلولي و ملكولي ( واحد)
    • 1396
      چوپانكاره, شادي
      اثر تحريك الكتريكي اپيتليوم و پياز بويايي بر شدت تشنج و اختلال يادگيري و حافظه در موش هاي صحرايي صرعي شده توسط پيلوكارپين
    • 1397
      زارعي, پريسا
    • مدیر گروه فیزیولوژی
    • عضویت در شورای نظارت و ارزیابی دانشکده پزشکی
    • عضو هیات تحریریه مجله دانش و تندرستی
    • عضو هیات تحریریه مجله Physiology and Pharmacology
    • عضو هیات تحریریه مجله علمی پژوهشی کومش
    • مدیر گروه فیزیولوژی
    • برگزیده جشنواره جوان خوارزمی سال 1378

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