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  • دکتری (1383)

    حشره شناسی پزشکی و مبارزه با ناقلین - حشره شناسی پزشکی

    نیوکاسل اپن تاین، انگلستان

  • کارشناسی‌ارشد (1373)

    حشره شناسی کشاورزی - اکولوژی و کنترل بیولوژیک

    نیوکاسل اپن تاین، انگلستان

  • کارشناسی (1364)

    مهندسی کشاورزی ، گیاه پزشکی

    دانشگاه شهید چمران اهواز،

  • ارزیابی سمیت داروها و مواد بیولوژیکی جدید با روشهای سلولی- مولکولی
  • پایش، غربالگری و اپیدمیولوژی بیماریها
  • آزمایشگاه اینسکتاریوم
  • حشره شناسی

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ارتباط

رزومه

New Candidates for Furin Inhibition as Probable Treat for COVID-19: Docking Output

MR Dayer
Journal Papers , , {Pages }

Abstract

An Accessible Prescription for COVID-19

MR Dayer
Journal Papers , , {Pages }

Abstract

Old Drugs for Newly Emerging Viral Disease, COVID-19: Bioinformatic Prospective

Mohammad Reza Dayer
Journal Papershttps://arxiv.org/abs/2003.04524 , 2020 March 10, {Pages }

Abstract

Coronavirus (COVID-19) outbreak in late 2019 and 2020 comprises a serious and more likely a pandemic threat worldwide. Given that the disease has not approved vaccines or drugs up to now, any efforts for drug design and or clinical trails of old drugs based on their mechanism of action are worthy and creditable in such circumstances. Experienced docking experiments using the newly released coordinate structure for COVID-19 protease as a receptor and thoughtfully selected chemicals among antiviral and antibiotics drugs as ligands may be leading in this context. We selected nine drugs from HIV-1 protease inhibitors and twenty-one candidates from anti bronchitis drugs based on their chemical structures and enrolled them in blind and active sit

Coronavirus (2019-nCoV) Deactivation via Spike Glycoprotein Shielding by Old Drugs, Bioinformatic Study

Mohammad Reza Dayer
Journal Papershttps://www.preprints.org/manuscript/202005.0020/v1 , Issue doi: 10.20944/prepri, 2020 April 30, {Pages }

Abstract

The disease of COVID-19 comprises the most serious against human health worldwide with a high rate of virulence and mortality. The disease is caused by the 2019-nCoV virus from the beta coronavirus family. The virus makes use of its surface glycoprotein named S protein or spike to enter the human cells. The virus attached to its receptor named angiotensin-converting enzyme 2 on host cells surface via its receptor-binding domain and its fusion is mediated by cleavage at S2'site that is carried out by surface protease. Vaccines or drugs interfering with S protein binding or cleavage sites could be considered as drugs to get rid of the infection. In the current work and though docking and molecular dynamic experiments we have checked more than

Old Drugs for JAK-STAT Pathway Inhibition in COVID-19 Patients

Mohammad Reza Dayer
Journal PapersPreprint , Issue DOI: 10.13140/RG.2.2, 2020 October , {Pages }

Abstract

Statisti-cal Analyses for Gender Dependent Risk of Non-Alcoholic Fatty Liver in Non-Diabetic Patients

MR Dayer, VS Nazemi, MS Dayer, SM Reza Alavi
Journal PapersJSM Endocrinol Diabetes Obes , Volume 1 , Issue 7, 2019 January , {Pages }

Abstract

Background: Non-alcoholic fatty liver is a chronic lifestyle disease caused by low physical activity and high food intake, which exposes patients to obesity and diabetes mellitus. High incidences and serious consequences of the disease have attracted a great number of new researches. elucidating mechanism for gender dependent risk of the disease is the main endeavor of this study.Methods: In the present study 286 male and 324 female individuals, aged 45?5 years with 13?1.5 and 8?2 mmHg (systolic/diastolic) blood pressure and BMI exceeding 22 were examined. The patients were non-diabetic with increased plasma concentrations of hepatic enzymes, their ratio of aspartate amino transferase (AST) to alanine amino transferase (ALT) was under unity

Investigating the Effect of Experimental Hypothyroidism on Insulin/Thyroid Hormones and Hepatic Steatosis

Vahideh Sadat Nazemi, Mohammad Reza Dayer, Tayebeh Mohammadi
Journal PapersZahedan Journal of Research in Medical Sciences , Volume 21 , Issue 1, 2019 January 31, {Pages }

Abstract

Background: The close physiological and biochemical relationships between insulin/thyroid hormones and intermediary metabolism, as well as hepatic homeostasis, are well documented. Apart from significant changes in thyroid hormones levels and altered insulin secretion or resistance, there is no consistency regarding the presence of hepatic storage diseases and fatty liver in hypothyroid patients. Objectives: The main objective of the current study was to evaluate the effect of experimental hypothyroidism on insulin level and histological alterations in the liver such as changes in lipid and glycogen reservoirs. Methods: In this study, 20 adult male Wistar rats were assigned to two similar groups including control and hypothyroid. Experiment

Effects of experimental hypothyroidism on insulin, glucose tolerance test and pancreatic tissue in adult male rats

VS Nazemi, MR Dayer, T Mohammadi
Journal Papers , , {Pages }

Abstract

Effect of Zinc Supplementation on Hepatic Enzymes in Healthy Rats

H Dabirinejad, MR DAYER, T Mohammadi
Journal Papers , Volume 10 , Issue 200550, 2018 January 1, {Pages 15-24 }

Abstract

Zinc ion is the second essential element in living organisms and is necessary for lots of enzymes activity eg alkaline phosphatase and lactate dehydrogenase. This ion also takes part in biological processes as human growth, immune response, and nerve function. Zinc deficiency causes significant decrease in serum alkaline phosphatase or increase in aspartate aminotransferase and alanine aminotransferase activity. Increase in these two later enzymes, in turn, is an indicator of tissue damage even though there are controversies among researchers. Accordingly, we decided to study the effect of 0. 6 gm/L of zinc sulfate in drinking water in a period of 3 months treatment on serum activities of hepatic enzymes in adult rats. Twenty female rats we

Sex-Related Risk of Myocardial Infarction: Insights from Path Analysis

MR Dayer, N Vahideh-Sadat, MS Dayer, SMR Alavi
Journal PapersInt Arch Cardiovasc Dis , Volume 2 , Issue 011, 2018 January , {Pages }

Abstract

Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic and non-hypothyroid male (174) and female patients (213). Among the determinant parameters, TSH, BUN, Creatinine, AST, ALT, FBS, LDL, and TG/HDL ratio, which show correlation and suit structural equation models were selected for path analysis. The av

Bis-substituted diphenylamine arylidene hydrazones for the synthesis of new binuclear organotin (IV) complexes: Crystal structure, DNA cleavage and molecular docking

Maryam Yousefi, Tahereh Sedaghat, Jim Simpson, Hossein Motamedi, Mohammad Reza Dayer
Journal PapersPolyhedron , Volume 155 , 2018 November 15, {Pages 153-162 }

Abstract

Five dinuclear organotin(IV) complexes, R4Sn2La (R = Me, Ph) and R4Sn2Lb (R = Me, Ph and Bu) have been synthesized from reaction of R2SnCl2 with 2,4′- and 2,2′-bis-substituted diphenylamine arylidene hydrazones, H4La and H4Lb, respectively. The synthesized compounds have been investigated by elemental analysis and IR, 1H NMR, and 119Sn NMR spectroscopy. The structures of Me4Sn2Lb and Ph4Sn2Lb have been also confirmed by X-ray crystallography. The results show that the fully deprotonated bis-hydrazone ligand provides two contiguous ONO tridentate domains that coordinate to the two SnR2 moieties in the enolate form. Each tin atom in the complexes adopts a five-coordinate environment. Ligands and complexes showed no antibacterial a

Investigation on the Effect of Captopril on the Production of IFN-γ and IL-10.

Mahboubeh Baheri, Mohammad Reza Dayer, Abdolkarim Sheykhi, Tayebeh Toyserkani
Journal PapersIranian Journal of Allergy, Asthma & Immunology , Volume 17 , 2018 January 2, {Pages }

Abstract

Abstract Objective: Multiple Sclerosis, a chronic autoimmune neurodegenerative inflammatory disease, is the main reason of physical disability in young adults. Have been many efforts to find a better understanding of disease and subsequently effective drugs. Surprisingly Angiotensin converting enzyme (ACE) inhibitors have recently attracted attentions for their immunomodulatory effects, besides to their known effectiveness on hypertension. Captopril is one of the well-known ACE inhibitors which is used as an effective drug, for hypertension and congestive heart failure. Inconsistent results have been reported about the effect of captopril on cytokines. Material and Methods: Blood samples were collected from 20 patients diagnosed as MS patie

Study the Effect of Ascorbic Acid on the Production of Cytokines in Multiple Sclerosis Patients.

Mahboubeh Baheri, Mohammad Reza Dayer, Abdolkarim Sheykhi, Farzaneh Habib Elahi, Tayebeh Toyserkani
Journal PapersIranian Journal of Allergy, Asthma & Immunology , Volume 17 , 2018 January 2, {Pages }

Abstract

Abstract Objective: Multiple Sclerosis, a chronic autoimmune neurodegenerative inflammatory disease, is the main reason of physical disability in young adults. More than 2 million people are affected worldwide and the rate of the disease is rather high, about 70 of 100000 in Tehran and Isfahan. Ascorbic Acid, known as vitamin C, is one of important required vitamins for humans, which must be received by food. One of the probable characteristics is anti-inflammatory activity. Since Cytokines as the key molecules in the process of inflammation and autoimmune diseases, can be appropriate targets to follow the process, have been used to check the effect of compounds on inflammation. Inconsistent results have been reported about the effect of ca

Protective or Deteriorative Effect of Zinc Ions on Protein Misfolding: A New Insight into Amyloidogenic Disease

Sepideh Noorzadeh, Mohammad Reza Dayer, Saeed Aminzadeh
Journal PapersJentashapir Journal of Health Research , Volume 8 , Issue 4, 2017 August , {Pages }

Abstract

Insulin as a small molecule with 51 residues is an interesting model useful in studying protein misfolding of neurodegenerative amyloid proteins. Investigating zinc effects on insulin misfolding and aggregation triggered by 80% ethanol is the main objective of the present work. Using different methods of turbidity measurement, examining thioflavin T fluorescence changes during insulin aggregation, and conducting Far-UV circular dichroism spectroscopy of the process, we studied insulin aggregations in the presence of micromolar and millimolar concentrations of zinc ions to shed light on the mechanism of misfolding in these circumstances. Our findings confirmed that millimolar concentrations of zinc protect insulin integrity against acidic pH

Lopinavir; A Potent Drug against Coronavirus Infection: Insight from Molecular Docking Study

Mohammad Reza Dayer, Sara Taleb-Gassabi, Mohammad Saaid Dayer
Journal PapersArchives of Clinical Infectious Diseases , Volume 12 , Issue 4, 2017 January , {Pages }

Abstract

Background: The severe acute respiratory syndrome (SARS) is a life threatening viral infection caused by a positive, single stranded RNA virus from the enveloped coronaviruse family. Associated with fever, cough, and respiratory complications, the illness causes more than 15% mortality worldwide. So far, there is no remedy for the illness except supportive treatments. However, the main viral proteinase has recently been regarded as a suitable target for drug design against SARS infection due to its vital role in polyproteins processing necessary for coronavirus reproduction.Objectives: The present in silico study was designed to evaluate the effects of anti HIV-1 proteases inhibitors, approved for clinical applications by US FDA, on SARS pr

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Mohammad Reza Dayer, Fatemeh Dehghani, Daryush Daer, Mohammad Saaid Dayer, Sayed Mohammad Reza Alavi
Journal PapersZahedan Journal of Research in Medical Sciences , Volume 19 , Issue 9, 2017 January , {Pages }

Abstract

Background: Androgenetic alopecia is the main cause of hair loss and common baldness that affects psychological more than physiological aspects of people’s lives. Studies have shown that this multi factorial disorder is initiated by androgens secretion in pubertal period, minerals limitations, autoimmunity, mental stress, genetic predisposition and some alterations in hematological factors.Objectives: The aim of this study was to evaluate the involvement of hematologic parameters in this disease using a case control study design.Methods: In this case-controlled study, two groups each of 80 individuals with androgenetic alopecia were voluntarily included in the study based on their medical histories and clinical examinations and subjected

Comparison of Complications and Surgical Outcomes of Percutaneous Nephrolithotomy with and Without Nephrostomy: A Double-Blind Randomized Controlled Trial

Esmaeil Mousapour, Mohammad Sadegh Mahfuzi, Mokhtar Hoseini, Pouria Mousapour
Journal PapersJentashapir Journal of Health Research , Volume 8 , Issue 4, 2017 August , {Pages }

Abstract

Background: Percutaneous nephrolithotomy (PCNL) has been established as a minimally invasive treatment option for removal of kidney stones. The aim of this research was to compare complications and surgical outcomes of standard PCNL with tubeless PCNL.Methods: In this double-blind randomized controlled trial, 50 consecutive patients with kidney stone were randomly assigned to intervention and control groups. In the control group, a nephrostomy was placed at the end of PCNL and in the intervention group, nephrostomy was omitted. Incidence of fever, hospital stay, analgesic requirement, blood transfusion, urinary leakage, and patient’s satisfaction were compared between the 2 groups.Results: Pain score was significantly lower in the tubeles

Comparison of newly assembled full length HIV-1 integrase with prototype foamy virus integrase: structure-function prospective

Mohammad Reza Dayer
Journal PapersJundishapur journal of microbiology , Volume 9 , Issue 5, 2016 May , {Pages }

Abstract

BackgroundDrug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, similar to HIV-1 of a prototype foamy virus integrase in complex with DNA, including all conservative residues, is available and has been extensively used in recent investigations.ObjectivesThe aim of this study was to determine whether the above model is precisely representative of HIV-1 integrase. This would critically determine the success of any designed drug using the model in deactivation of integrase and AIDS treatment.M

Temperature and pH effects on insulin structure: a molecular dynamic approach

Mahboubeh Baheri, Mohammad Reza Dayer
Journal PapersJentashapir Journal of Health Research , Volume 7 , Issue 4, 2016 January , {Pages }

Abstract

Background: Protein misfolding and aggregation are the main causes of serious diseases; thus the study of mechanism and effective factors is necessary to find the cure. Since most of the proteins have the ability to produce aggregations, available and non-infectious proteins can be studied as models. Insulin is one of the best models in this field.Methods: The current study evaluated the effect of three temperatures of 0 C, 37 C and 47 C and neutral and acidic pH on insulin structure and misfolding by silico simulation. An insulin structure obtained by nuclear magnetic resonance (NMR) spectroscopy is simulated by GROMACS package under different conditions. The secondary structure of insulin amino acids was studied in acidic and neutral cond

SIMULATION OF HIV-I INTEGRASE INTERACTION WITH ITS INHIBITORS USING MOLECULAR DYNAMIC METHODS

MR DAYER
Journal Papers , Volume 12 , Issue 2330025, 2016 January 1, {Pages 35-46 }

Abstract

Application of newly designed enzyme inhibitors against viral enzymes is one of the modern and effective approaches in viral diseases treatment. Such inhibitors, by inactivating vital enzymes and interrupting viral proliferation, prevent the spread of infection. In this context, the HIV-1 integrase is of special importance. So far, three inhibitors against integrase were designed, approved and used clinically named: Raltegravir, Elvitegravir, and Dolutegravir. In present work and in order to study the action mechanisms for these inhibitors we at first performed serial docking experiments to find the best binding sites for these inhibitors and to extract their complexes with integrase. Next we simulated these complexes for 10ns period at nat

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دروس نیمسال جاری

  • كارشناسي ارشد
    اكولوژي حشرات ( واحد)
    دانشکده علوم پزشکی، گروه حشره شناسي پزشكي
  • كارشناسي ارشد
    بيوشيمي آفت كش ها ( واحد)
  • كارشناسي ارشد
    كارآموزي ( واحد)

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  • كارشناسي ارشد
    حشره شناسي پزشكي ( واحد)
    دانشکده علوم پزشکی، گروه حشره شناسي پزشكي
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    حشره شناسي پزشكي ( واحد)
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    اصول مبارزه بيولوژيك ( واحد)
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